Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Carboxypeptidase A1 (CPA1)
- Target
- CPA1
- Molecular classification
- Enzyme, Metalloprotease, Exopeptidase
01
Overview
Carboxypeptidase A1 (CPA1) is a zinc-dependent metalloprotease enzyme primarily produced in the pancreas. It plays a key role in protein digestion by cleaving C-terminal branched-chain and aromatic amino acids from dietary proteins. It is also involved in zymogen inhibition, being synthesized as an inactive precursor to prevent autodigestion of pancreatic tissue. Mutations in CPA1 have been linked to chronic pancreatitis, and elevated serum levels are observed in pancreatic cancer. Immunohistochemical staining for CPA1 serves as a diagnostic marker for pancreatic acinar cell carcinoma.
- Other names
- Carboxypeptidase APancreatic Carboxypeptidase AProcarboxypeptidase APancreatic Carboxypeptidase A1
02
Mechanism of action
Hydrolyzes peptide bonds at the C-terminal end of proteins, specifically targeting branched-chain and aromatic amino acids.
03
Biological functions
Protein digestionZymogen activation
04
Disease associations
Pancreatic cancerChronic pancreatitis
05
Biomarkers
Elevated serum CPA1 levels in pancreatic cancerCPA1 immunohistochemical staining for acinar cell carcinoma
Beyond the preview
Go deeper on Carboxypeptidase A1 (CPA1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Carboxypeptidase A1 (CPA1).