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Target intelligence / Profile preview
Thrombin Activatable Fibrinolysis Inhibitor (TAFI)
- Target
- TAFI
- Molecular classification
- Enzyme, Metallocarboxypeptidase, Zymogen
01
Overview
Thrombin activatable fibrinolysis inhibitor (TAFI) is a plasma enzyme that plays a crucial role in regulating the balance between coagulation and fibrinolysis. It circulates as an inactive zymogen and is activated by thrombin or plasmin. TAFIa functions as a metallocarboxypeptidase that removes C-terminal lysine or arginine residues from peptide substrates, primarily attenuating fibrinolysis. Elevated levels or activity are associated with increased risk for thrombotic diseases. TAFI/TAFIa also participates in inflammatory processes.
- Other names
- Carboxypeptidase B2CPB2Carboxypeptidase UCPUPlasma carboxypeptidase BpCPBProcarboxypeptidase Rpro-CPRCPR
02
Mechanism of action
Inhibition of TAFI activation or enzymatic activity, leading to enhanced fibrinolysis.
03
Biological functions
Regulation of fibrinolysisModulation of inflammationRegulation of hemostasisInhibition of clot breakdown
04
Disease associations
Thrombotic diseasesVenous thrombosisArterial thrombosisInflammation
05
Safety considerations
Potential for increased bleeding risk with excessive inhibitionNeed for careful dose titration to avoid disrupting hemostatic balance
06
Interacting drugs
TAFI inhibitors (experimental)
07
Biomarkers
TAFI levelsTAFIa activity
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