Carboxypeptidase B2 (CPB2)

Carboxypeptidase B2 (CPB2), also known as Carboxypeptidase U (CPU), Plasma carboxypeptidase B (pCPB), or Thrombin-activatable fibrinolysis inhibitor (TAFI), is a human enzyme that plays important roles in regulating fibrinolysis and modulating the activity of biologically active peptides. It is a metallocarboxypeptidase that cleaves C-terminal basic amino acids, specifically arginine or lysine, from peptides and proteins. CPB2 is synthesized as an inactive zymogen and activated by proteolytic cleavage. After activation, it downregulates fibrinolysis by reducing plasminogen binding to fibrin and regulates peptide hormones by cleaving C-terminal arginine or lysine residues. Genetic polymorphisms in CPB2 may influence individual susceptibility to thrombosis or bleeding disorders.

Other names

CPUpCPBTAFICarboxypeptidase UPlasma carboxypeptidase BThrombin-activatable fibrinolysis inhibitor

Inhibition of carboxypeptidase activity, modulation of fibrinolysis, regulation of peptide hormone activity