Carboxypeptidase X, M14 family member 2 (CPXM2)

Carboxypeptidase X, M14 family member 2 (CPXM2) is a protein encoded by the CPXM2 gene in humans, structurally related to M14 metallocarboxypeptidases but lacking the active site and zinc-binding residues required for enzymatic activity[5]. It is not an active carboxypeptidase but is predicted to participate in cell-cell interactions and extracellular matrix organization. CPXM2 is expressed in various tissues and is upregulated in cardiac hypertrophy, implicating it as a potential therapeutic target for cardiac remodeling and failure. Mutations and dysregulation of CPXM2 are associated with diseases such as ectodermal dysplasia and chromosomal duplication syndromes. Currently, no drugs directly target CPXM2, and its precise biological function remains under investigation, with recent knockout animal models supporting its role in cardiac disease risk and progression[5][1][3][2][4].

Other names

CPX2Inactive carboxypeptidase-like protein X2UNQ676/PRO1310UNQ676Cytosolic carboxypeptidase4632435C11RikCarboxypeptidase HloCarboxypeptidase-like protein X2CPXM2_HUMAN (UniProt)Chromosome 2Q35 duplication syndrome gene

Not established (no known drugs; molecular modulation would likely target gene expression, cell signaling, or protein-protein interaction; knockout models show protection against cardiac hypertrophy, suggesting a target for future therapies)