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Target intelligence / Profile preview
Carcinoembryonic Antigen (CEA)
- Target
- CEA
- Molecular classification
- Glycoprotein, Immunoglobulin superfamily, Cell adhesion molecule
01
Overview
Carcinoembryonic antigen (CEA) is a set of highly related glycoproteins primarily involved in cell adhesion. CEA is normally produced in gastrointestinal tissue during fetal development, with production ceasing before birth. In healthy adults, CEA levels are typically very low, but can be elevated in certain cancers and some benign conditions. It is primarily used as a tumor marker for monitoring treatment response and detecting recurrence, but has limitations due to its elevation in non-cancerous conditions.
- Other names
- CD66aCD66bCD66cCD66dCD66eCD66fCD66 cluster proteins
02
Biological functions
Cell adhesionTumor-endothelial interactionsL-selectin ligandE-selectin ligand
03
Disease associations
CancerColorectal cancerBreast cancerLung cancerPancreatic cancerStomach cancerLiver cancerOvarian cancer
04
Safety considerations
Elevated levels can occur in benign conditionsNot suitable for general population screeningNot a definitive diagnostic tool
05
Biomarkers
Tumor marker for monitoring treatment responseTumor marker for detecting recurrence after therapyPrognostic marker in cancer
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