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Target intelligence / Profile preview
Carcinoembryonic Antigen Cell Adhesion Molecule 1 (CEACAM1)
- Target
- CEACAM1
- Molecular classification
- Type I membrane glycoprotein, Immunoglobulin superfamily, CEA family, Cell adhesion molecule, Receptor
01
Overview
CEACAM1 is a member of the carcinoembryonic antigen (CEA) gene family and belongs to the immunoglobulin superfamily. It is a type I transmembrane glycoprotein involved in cell adhesion, signal transduction, and immune regulation. It plays roles in both innate and adaptive immunity, tumor biology, and angiogenesis. Its interactions with TIM-3 and other proteins make it a potential therapeutic target for cancer immunotherapy, autoimmune diseases, and infectious diseases.
- Other names
- CD66abiliary glycoprotein
02
Mechanism of action
Modulation of immune checkpoint pathways, inhibition of T-cell exhaustion, modulation of cell adhesion and signaling.
03
Biological functions
Cell adhesionSignal transductionImmune modulationAngiogenesisRegulation of innate/adaptive immunityRegulation of tolerance pathwaysNeutrophil activationRegulation of granulopoiesis
04
Disease associations
CancerAutoimmune diseaseInfectious disease
05
Safety considerations
Potential adverse effects due to broad tissue distributionMicrobial exploitation for host invasion/immune evasion
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