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Target intelligence / Profile preview
Carcinoembryonic antigen-related cell adhesion molecule 18 (CEACAM18)
- Target
- CEACAM18
- Molecular classification
- Immunoglobulin superfamily, Cell adhesion molecule, Transmembrane protein
01
Overview
Carcinoembryonic antigen-related cell adhesion molecule 18 (CEACAM18) is a transmembrane protein belonging to the CEACAM family, part of the larger immunoglobulin superfamily[1][4]. It contains one immunoglobulin V-like and two immunoglobulin C2-like extracellular domains, as well as a short cytoplasmic tail[1]. CEACAM family members are implicated in cell-cell adhesion, immune regulation, angiogenesis, cell growth, differentiation, and apoptosis[1][4][6]. While the specific function of CEACAM18 remains under investigation, its structure suggests potential roles in cell adhesion and as a receptor for pathogen recognition or immunoregulatory molecules[1]. It has been identified, along with other CEACAMs, as a biomarker for colorectal cancer and may play a part in diverse intracellular signaling pathways, though no specific drug interactions or therapeutic developments have been reported for CEACAM18 to date[1][4][7].
- Other names
- CEA cell adhesion molecule 18Cell adhesion molecule CEACAM18CEACAM18Carcinoembryonic antigen-related cell adhesion molecule 18
02
Biological functions
Cell adhesionIntracellular signalingPossible immune regulationPotential pathogen recognition
03
Disease associations
Cancer (biomarker association)Possible roles in immune disorders (inferred from family functions)
04
Biomarkers
Colorectal cancer (as a biomarker, inferred from CEACAM family)
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