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Carcinoembryonic Antigen Related Cell Adhesion Molecule 5 (CEACAM5)
- Target
- CEACAM5
- Molecular classification
- Cell surface glycoprotein, Cell adhesion molecule, CEA family member
01
Overview
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is a cell surface glycoprotein involved in cell adhesion and signaling. It is highly expressed in various epithelial tissues, particularly in the gastrointestinal tract and squamous epithelia. CEACAM5 plays a role in cell-cell adhesion and inhibits differentiation and apoptosis. It is overexpressed in many adenocarcinomas, including colorectal cancer and non-small-cell lung cancer, and is widely used as a biomarker for cancer diagnosis, prognosis, and monitoring. It is the target of investigational imaging agents for intraoperative tumor localization.
- Other names
- CD66eCEA (Carcinoembryonic Antigen)
02
Mechanism of action
Targeted by imaging agents for intraoperative tumor localization; being investigated for targeted therapies
03
Biological functions
Cell-cell adhesionInhibition of differentiationInhibition of apoptosis
04
Disease associations
CancerColorectal cancerNon-small-cell lung cancer (NSCLC)Adenocarcinoma
05
Safety considerations
Off-target effectsLimited efficacy in some cancers
06
Biomarkers
Serum CEA levels (diagnosis/prognosis/monitoring)Tissue CEACAM5 expression (immunohistochemistry)
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