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Target intelligence / Profile preview
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)
- Target
- CEACAM6
- Molecular classification
- Carcinoembryonic antigen (CEA) family, Immunoglobulin superfamily, Cell adhesion molecule, Glycoprotein
01
Overview
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as CD66c and NCA-90, is a glycoprotein belonging to the carcinoembryonic antigen (CEA) family of cell adhesion molecules. It plays significant roles in cell adhesion, immune modulation, and cancer progression. Its overexpression is correlated with poor prognosis in several tumor types, making it a promising diagnostic/prognostic biomarker and therapeutic target.
- Other names
- CD66cNCA-90
02
Mechanism of action
Blocking or downregulating CEACAM6 to reactivate anti-tumor immunity by restoring T-cell responses against tumors.
03
Biological functions
Cell adhesionImmune modulationTumor cell growthMigration/invasionMetastasisAngiogenesis regulationAltered differentiationLymphocyte activationTumor suppression/promotionNeutrophil activity regulation
04
Disease associations
CancerCOVID-19 pathogenesisInfectionInflammation
05
Safety considerations
Potential for off-target effects due to interactions with other CEACAM family members.
06
Biomarkers
Diagnostic biomarker for malignancy detectionPrognostic biomarker for malignancy detectionMetastasisPoor survival
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