Carcinoembryonic antigen-related cell adhesion molecule pseudogene 1 (CEACAM22P)

Carcinoembryonic antigen-related cell adhesion molecule pseudogene 1 (CEACAMP1, also CEACAM22P, CGM8) is a non-coding pseudogene within the carcinoembryonic antigen (CEA) gene family, often referenced as "CEACAM22P" or "carcinoembryonic antigen gene family member 8 (pseudogene)." It is not a protein-coding gene and is therefore not considered a validated therapeutic target, receptor, or functional molecule. It is located within the cluster of the CEA gene family on human chromosome 19. Unlike functional members of the CEACAM family such as CEACAM1, CEACAMP1 does not encode a cell surface protein and has no established biological function or therapeutic relevance. The inclusion of "receptor" or "cell adhesion molecule" in this context reflects its sequence similarity to active CEACAM family proteins but should not be confused with the functional molecule CEACAM1 (CD66a), which is a well-validated cell adhesion molecule involved in immune regulation, cancer biology, angiogenesis, and other functions. Pseudogenes commonly arise from gene duplication events and do not typically produce functional proteins, though some may play regulatory roles at the RNA level; no such role is supported for CEACAMP1 in the available literature[1][2][3]. Key clarification: This entry is often misattributed as a functional receptor or cell adhesion molecule relevant to cancer or immunity; the actual protein of interest for those roles is Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1, CD66a), not CEACAMP1/CEACAM22P[1][2][3].

Other names

CEACAMP1CEACAM22PCGM8carcinoembryonic antigen gene family member 8 (pseudogene)carcinoembryonic antigen related cell adhesion molecule pseudogene 1carcinoembryonic antigen-related cell adhesion molecule 22, pseudogene