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CARD11 antisense RNA 1 (CARD11-AS1)

Target
CARD11-AS1
Molecular classification
Long non-coding RNA (lncRNA)
01

Overview

CARD11 antisense RNA 1 is a long non-coding RNA (lncRNA) gene identified as CARD11-AS1. It does not encode a protein, and its biological function remains largely uncharacterized. Some associations with B-cell expansion and NF-κB signaling are noted, and there is emerging evidence for differential expression in certain cancer types, but it is not considered a therapeutic or druggable target based on current knowledge. CARD11-AS1 is distinct from the CARD11 protein-coding gene, which has established roles in immune signaling, but CARD11-AS1 itself is a non-coding transcript with no known direct therapeutic applications.

Other names
CARD11-AS1
02

Biological functions

Regulation of gene expression (typical of lncRNAs, but specific roles for CARD11-AS1 are not detailed in current sources)
03

Disease associations

B-cell expansion with NF-κB and T-cell anergy (reported disease relevance, but not as an actionable target)Differential expression in some cancers, though details are very limited in current databases

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