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Target intelligence / Profile preview
CARD11-BCL10-MALT1 Complex (CBM Complex)
- Target
- CBM Complex
- Molecular classification
- Multi-protein complex, Scaffold protein complex, Signaling complex
01
Overview
The CARD11-BCL10-MALT1 (CBM) complex is a multi-protein assembly essential for antigen receptor-mediated signaling in lymphocytes. It functions as a central hub for activating NF-κB, JNK, and mTOR pathways upon TCR or BCR stimulation. The complex is composed of CARD11, BCL10, and MALT1, and its assembly is initiated by antigen receptor engagement leading to downstream effects on immune cell proliferation, differentiation, and survival. Dysregulation of the CBM complex can result in immunodeficiency or malignancies such as diffuse large B-cell lymphoma.
- Other names
- CARMA1-BCL10-MALT1 ComplexSignalosomeCARD11 Signalosome
02
Mechanism of action
Inhibition of CBM complex formation or MALT1 protease activity
03
Biological functions
NF-κB pathway activationTCR signalingBCR signalingImmune response regulationSignal transduction
04
Disease associations
LymphomaImmunodeficiencyDiffuse large B-cell lymphoma (DLBCL)CancerAutoimmune diseases
05
Safety considerations
ImmunosuppressionOff-target effects
06
Interacting drugs
MALT1 inhibitors
07
Biomarkers
CARD11 mutationsBCL10 expressionMALT1 expression
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