Target intelligence / Profile preview

Cardiac and vascular function

01

Overview

Cardiac and vascular function refers to the integrated physiological processes of the heart and blood vessels that maintain systemic circulation and blood pressure. This term describes a broad physiological system or therapeutic area rather than a specific molecular target such as a receptor, enzyme, or transporter (StatPearls: Physiology, Cardiac Output). It encompasses the mechanical pumping of the heart, the electrical conduction system, and the regulation of vascular tone and resistance. While many drugs are designed to modulate these functions to treat conditions like hypertension or heart failure, "Cardiac and vascular function" itself is a physiological outcome. In drug development, specific targets within this system—such as beta-adrenergic receptors, angiotensin-converting enzymes, or ion channels—are identified for therapeutic intervention (NIH: Cardiovascular Medications). Therefore, this entry is categorized as incorrect because it lacks the specificity required for a molecular drug target.

Other names
Cardiovascular functionCirculatory system functionHeart and blood vessel function
02

Mechanism of action

Not applicable as this is a physiological system, not a molecular target.

03

Biological functions

Systemic blood circulationBlood pressure homeostasisCardiac output regulationTissue perfusion and nutrient delivery
04

Disease associations

Cardiovascular diseaseHypertensionHeart failureMyocardial infarctionArrhythmia
05

Safety considerations

CardiotoxicityHemodynamic instabilityOrthostatic hypotensionArrhythmogenic potential
06

Biomarkers

Blood pressureHeart rateLeft ventricular ejection fraction (LVEF)Troponin I/TB-type natriuretic peptide (BNP)

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