Cardiac fibroblast proliferation

Cardiac fibroblast proliferation refers to the increase in the number of cardiac fibroblasts, a process central to cardiac development, repair, and disease. After cardiac injury (e.g., myocardial infarction), resident cardiac fibroblasts proliferate, migrate, and produce extracellular matrix (ECM) to maintain structural integrity and contribute to scar formation. Dysregulated proliferation plays a key role in pathological cardiac fibrosis, which impairs cardiac function and can lead to heart failure. This proliferation is driven by growth factors, cell-matrix interactions, and mechanical cues. Molecular mediators include PDGFRα, TGF-β, and various ECM proteins. While modulation of this process offers therapeutic potential, it is not a direct drug target but rather a process governed by multiple signaling molecules and pathways

Other names

Cardiac fibroblast expansionCardiac fibroblast growthCardiac fibroblast cell divisionCardiac fibrogenesis

Not applicable directly. Mechanisms of action relevant to the process include: Inhibition of growth factor signaling (e.g., blockade of PDGFRα or TGF-β pathways), Modulation of ECM production, Inhibition of fibroblast activation