Cardiac hypertrophy-associated epigenetic regulator (Chaer)

Cardiac hypertrophy-associated epigenetic regulator (Chaer) is a heart-enriched long noncoding RNA that plays a crucial role in the development of pathological cardiac hypertrophy. Chaer directly interacts with the catalytic subunit of polycomb repressor complex 2 (PRC2), hindering its targeting to genomic loci and thereby inhibiting histone H3 lysine 27 methylation at promoters of hypertrophy-related genes. This lncRNA-mediated interaction is stress- and hormone-responsive, contributing to epigenetic reprogramming required for cardiac hypertrophy onset. Silencing Chaer, particularly before cardiac stress, attenuates hypertrophy and cardiac dysfunction. As a non-coding RNA, Chaer is classified as an epigenetic regulator and offers a potential therapeutic target for heart failure and associated cardiac remodeling

Other names

Chaercardiac hypertrophy-associated epigenetic regulatorCHAER1

Inhibition or silencing of Chaer (e.g., antisense RNA or RNA interference) prior to cardiac stress reduces hypertrophy and fibrosis; acts through blocking PRC2 recruitment and histone H3K27 methylation