Cardiac ion channel pre-mRNA or RNA–protein complex

The “pre-mRNA or RNA–protein complexes of cardiac ion channels” refers to the messenger RNA transcripts of cardiac ion channel genes in their unspliced or partially spliced (pre-mRNA) form, along with the proteins (RNA-binding proteins, splicing factors) that associate with them to govern their processing, stability, and expression. These RNA-protein complexes regulate the amount and isoform diversity of sodium, potassium, and calcium ion channels crucial for cardiac electrical activity. Defects in pre-mRNA splicing or altered interactions with regulatory proteins can cause abnormal channel expression, contributing to arrhythmias and other cardiac diseases. The regulatory machinery and RNA-protein complexes are emerging drug targets, with the potential to correct pathological splicing or expression defects underlying inherited or acquired cardiac rhythm disorders[1][5].

Other names

Cardiac ion channel RNA–protein complexescardiac channel pre-mRNA RNPs

Modulation of splicing (alternative splice-site selection) Regulation of mRNA stability and decay Alteration of translation efficiency