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Target intelligence / Profile preview
Cardiac Ryanodine-Receptor Channel Type 2 (RyR2)
- Target
- RyR2
- Molecular classification
- Ion channel, Calcium channel, Receptor
01
Overview
The cardiac ryanodine-receptor channel type 2 (RyR2) is a large intracellular calcium release channel predominantly expressed in cardiac muscle cells. It plays a central role in excitation-contraction coupling by mediating the release of Ca²⁺ from the sarcoplasmic reticulum (SR) into the cytosol, which is essential for cardiac muscle contraction. Dysfunction or mutations in RYR2 are linked to several cardiovascular diseases: Catecholaminergic polymorphic ventricular tachycardia (CPVT), Atrial fibrillation, and Heart failure. Abnormalities may result from altered gating properties leading to inappropriate diastolic SR Ca²⁺ leak—contributing to arrhythmogenesis and contractile dysfunctions seen in heart disease patients.
- Other names
- Ryanodine receptor 2RYR2
02
Mechanism of action
Modulation of calcium release from the sarcoplasmic reticulum
03
Biological functions
Calcium signalingExcitation-contraction couplingMitochondrial metabolism regulationGene expression regulation
04
Disease associations
Catecholaminergic polymorphic ventricular tachycardia (CPVT)Atrial fibrillationHeart failureArrhythmogenesis
05
Safety considerations
ArrhythmogenesisPotential for diastolic SR Ca²⁺ leakCardiac dysfunction
06
Interacting drugs
Caffeine
2 more in the full profile.
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