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Target intelligence / Profile preview
Cardiac Troponin C (None)
- Target
- None
- Molecular classification
- Calcium-binding protein, Troponin subunit
01
Overview
Cardiac troponin C (cTnC) is a calcium-binding protein that regulates cardiac muscle contraction. It is a subunit of the troponin complex, which controls the interaction between actin and myosin filaments. cTnC senses cytoplasmic calcium levels, triggering conformational changes that relieve the inhibition of actomyosin ATPase, enabling muscle contraction. Mutations in TNNC1, the gene encoding cTnC, are associated with cardiomyopathies. Cardiac troponins, including TnI and TnT, are used as biomarkers for myocardial injury.
- Other names
- cTnCTNNC1
02
Mechanism of action
Modulation of thin filament regulation
03
Biological functions
Calcium sensingRegulation of cardiac muscle contractionExcitation-contraction coupling
04
Disease associations
CardiomyopathyHypertrophic cardiomyopathyDilated cardiomyopathyHeart failure
05
Safety considerations
Interference from autoantibodiesInterference from macrotroponins
06
Biomarkers
Cardiac troponins (TnI, TnT)
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