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Target intelligence / Profile preview
Cardiac Troponin Complex (cTn)
- Target
- cTn
- Molecular classification
- Structural Protein, Regulatory Protein
01
Overview
Cardiac troponin is a protein complex found in heart muscle cells that regulates cardiac muscle contraction and relaxation. It is composed of three subunits: troponin C (cTnC), troponin I (cTnI), and troponin T (cTnT). Cardiac-specific isoforms, especially cTnI and cTnT, are released into circulation when heart muscle cells are damaged, serving as sensitive and specific markers for myocardial injury. Measurement of serum cTnI/cTnT is a standard practice for diagnosing acute myocardial infarction.
- Other names
- Cardiac Troponin IcTnICardiac Troponin TcTnTc-TNIhs-c-TNT
02
Biological functions
Calcium-mediated muscle contractionRegulation of actomyosin ATPase activity
03
Disease associations
Myocardial infarctionMyocarditisCardiovascular disease
04
Safety considerations
Elevated levels can indicate various non-ischemic cardiac conditions, requiring careful differential diagnosis.
05
Biomarkers
Myocardial injuryAcute myocardial infarctionHeart failureMyocarditis
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