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Target intelligence / Profile preview
Troponin I type 3 (cardiac) (cTnI)
- Target
- cTnI
- Molecular classification
- Protein, Structural protein, Troponin subunit
01
Overview
Cardiac Troponin I (cTnI) is a cardiac-specific protein that is part of the troponin complex in cardiac muscle cells. It regulates heart muscle contraction by inhibiting actomyosin ATPase activity. cTnI is a highly specific biomarker for myocardial injury, and elevated blood levels indicate damage to cardiac myocytes, particularly during acute myocardial infarction. Mutations in the TNNI3 gene can cause inherited cardiomyopathies.
- Other names
- Cardiac troponin ITNNI3Troponin I, cardiac muscle
02
Mechanism of action
N/A
03
Biological functions
Regulation of muscle contractionInhibition of actomyosin ATPase activity
04
Disease associations
Cardiovascular diseaseCardiomyopathyMyocardial infarction
05
Safety considerations
Elevated levels indicate myocardial damageMutations can cause cardiomyopathy and sudden cardiac death
06
Biomarkers
Myocardial injuryAcute myocardial infarction
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