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Target intelligence / Profile preview
Cardiolipin
- Molecular classification
- Phospholipid
01
Overview
Cardiolipin is a unique phospholipid, also known as diphosphatidylglycerol, predominantly found in the inner mitochondrial membrane of eukaryotic cells. It constitutes about 20% of the total lipid composition in this membrane and is especially abundant in tissues with high energy demands such as heart and skeletal muscle. It plays crucial roles in mitochondrial structure, electron transport chain function, and membrane dynamics. As an autoantigen, antibodies against cardiolipin are associated with increased risk of various thrombotic and obstetric complications. Dysfunctional cardiolipin metabolism is implicated in diseases like Barth syndrome.
- Other names
- Diphosphatidylglycerol
02
Biological functions
Mitochondrial membrane stabilizationElectron transport chain supportMembrane dynamicsCristae structure maintenance
03
Disease associations
Barth syndromeAntiphospholipid syndromeThrombosisRecurrent miscarriageThrombocytopeniaPremature laborPre-eclampsiaDeep vein thrombosis (DVT)Pulmonary embolism (PE)
04
Safety considerations
Autoantigenicity leading to antiphospholipid syndrome and related complicationsDysfunctional metabolism implicated in Barth syndrome
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