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Cardiolipin Peroxidation (CL Peroxidation)
- Target
- CL Peroxidation
- Molecular classification
- Lipid modification, Oxidative stress process
01
Overview
Cardiolipin peroxidation refers to the oxidative modification of cardiolipin, a unique phospholipid predominantly found in the inner mitochondrial membrane. Cardiolipin is essential for mitochondrial function. Peroxidation disrupts mitochondrial membrane fluidity, ion permeability, impairs electron transport chain function, and promotes apoptosis. It is implicated in various diseases associated with energy deficiency or increased oxidative stress. Preventing or reversing cardiolipin peroxidation is an attractive therapeutic strategy.
- Other names
- Oxidized CardiolipinPeroxidized CardiolipinCardiolipin Oxidation
02
Mechanism of action
Preventing or reversing cardiolipin peroxidation to protect mitochondrial function and prevent apoptosis.
03
Biological functions
Mitochondrial dysfunctionApoptosis inductionCytochrome c releaseMitochondrial membrane permeabilization
04
Disease associations
Heart failureNeurodegenerative diseasesDiabetesIschemia-reperfusion injuryAging-related disorders
05
Safety considerations
Potential for disrupting mitochondrial function if targeted incorrectlyOff-target effects of antioxidants
06
Interacting drugs
SS-31 (Elamipretide)
1 more in the full profile.
07
Biomarkers
Levels of oxidized cardiolipinMarkers of mitochondrial dysfunction
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