Cardiomyocyte Cell Cycle Pathways

Cardiomyocyte cell cycle pathways refer to the molecular mechanisms and regulatory networks that control the proliferation, growth, and cell cycle progression of cardiomyocytes (heart muscle cells). In mammals, these pathways are highly active during embryonic and early postnatal development but become largely inactive in adult hearts, leading to a limited capacity for regeneration after injury. Key components include cyclins, cyclin-dependent kinases (CDKs), CDK inhibitors (INK4, Cip/Kip families), Retinoblastoma protein family, and E2F transcription factors. Major regulatory pathways involved are PI3K/AKT, Wnt/β-catenin, Hippo-YAP, and Neuregulin-ERBB. Reactivation of these pathways is a therapeutic strategy for cardiac regeneration after injury, but safety concerns need to be addressed.

Modulation of cardiomyocyte cell cycle regulators (e.g., Cyclins, CDKs, CDK inhibitors)