Cardiomyocyte Maturation Associated long non-coding RNA (CARMA)

Cardiomyocyte Maturation Associated lncRNA (CARMA) is a conserved long non-coding RNA located adjacent to MIR-1-1HG, the host gene for key cardiogenic microRNAs MIR1-1 and MIR-133a2. CARMA is transcribed antisense to these microRNAs and negatively regulates their expression. Knockdown of CARMA leads to increased expression of these microRNAs and further coordinate downregulation of their protein-coding targets, including RBPJ, a central effector in the NOTCH signaling pathway critical for cardiac development. CARMA thus forms part of a regulatory network involving lncRNAs, myomirs, and NOTCH pathway components, orchestrating the balance of differentiation and maturation in human pluripotent stem cell-derived cardiomyocytes[1]. Its function is critical for the specification of cardiac lineage and inhibition of neuroectodermal specification, but there is no evidence it acts as a classical therapeutic target such as a receptor, enzyme, or transporter[1][2].

Other names

CRMAFLJ30313CARDIOMYOCYTE MATURATION-ASSOCIATED lncRNAC20orf200NCRNA00335C20orf166-AS1MIR1-1HG-AS1Non-Protein Coding RNA 335Chromosome 20 Open Reading Frame 200C20orf166 Antisense RNA 1

not applicable (no known drugs or therapeutics target CARMA directly)