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Target intelligence / Profile preview
Cardiotrophin 2, pseudogene (CTF2P)
- Target
- CTF2P
- Molecular classification
- Other (Pseudogene; classified as a cytokine in other species but not functional in humans)
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Overview
Cardiotrophin 2, pseudogene (CTF2P) represents the human ortholog of the murine cytokine neuropoietin (cardiotrophin-2). While neuropoietin is a functional cytokine in mice and other mammals—acting via the CNTF receptor complex, LIF receptor, and gp130 to promote neural survival and proliferation—human CTF2P is rendered nonfunctional by an 8-base pair deletion that disrupts the coding sequence. As a result, CTF2P does not produce an active protein, has no known physiological or pathological functions, is not associated with any disease, and is not considered a direct therapeutic target in humans.
- Other names
- CTF2PNP (neuropoietin)Neuropoietin (ortholog of mouse neuropoietin, pseudogene in humans)Cardiotrophin-2, pseudogeneCTF2
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