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CarH Photoreceptor Protein (Bacterial) (None)

Target: None
Molecular classification: Transcription factor, Photoreceptor

Overview

CarH is a bacterial photoreceptor protein that uses adenosylcobalamin (AdoCbl) as its chromophore. It functions as a light-dependent transcriptional regulator, controlling the biosynthesis of carotenoids in bacteria to protect against photo-oxidative stress. In the dark, CarH binds AdoCbl and forms a homo-tetramer that represses transcription of carotenoid biosynthesis genes. Upon exposure to light, AdoCbl undergoes photolysis, triggering dissociation of the tetramer and allowing gene expression.

Mechanism of action

Light-dependent dissociation from DNA, leading to derepression of target genes

Biological functions

Transcriptional regulationLight-dependent gene expressionCarotenoid biosynthesis regulationPhoto-oxidative stress response

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