Cariogenic bacterial biofilm (occlusal surface)

The concept "Cariogenic bacteria colonization on occlusal surfaces" does not refer to a single molecule, receptor, or molecular target; instead, it describes the process by which cariogenic (cavity-causing) bacteria adhere to and multiply on the biting (occlusal) surfaces of teeth, forming biofilms that contribute to dental caries[2][3][4][5][6][7]. Cariogenic bacteria colonization on occlusal surfaces refers to the process by which acid-producing microorganisms, primarily members of the genus Streptococcus (especially *Streptococcus mutans*) and others such as *Lactobacillus*, *Veillonella*, *Actinomyces*, *Atopobium*, and *Bifidobacterium*, adhere to the pits, fissures, and grooves of occlusal tooth surfaces[1][2][3][4][5][6][7]. This colonization leads to the formation of biofilms, which metabolize dietary carbohydrates into acids, lowering the local pH and causing demineralization of tooth enamel, manifesting as dental caries. The composition and activity of these biofilms are influenced by diet (especially frequent intake of fermentable carbohydrates), poor oral hygiene, and the anatomical features of occlusal surfaces[2][4][5]. Current preventive strategies include mechanical removal of biofilm, topical antimicrobials, fluoride treatments, and dietary modification. This target description is not a molecule or receptor but an ecological phenomenon. For structured drug discovery information, researchers should refer to individual cariogenic species (e.g., *Streptococcus mutans*, *Lactobacillus acidophilus*) or their molecular products (e.g., glucosyltransferase, acid transporters), which may serve as valid molecular targets[2][4][6].

Other names

Dental caries biofilm (occlusal)Cariogenic plaque (occlusal surface)Occlusal bacterial colonization

Disruption of biofilm formation; Killing or inhibiting bacterial growth; Inhibition of bacterial acid production; Promotion of tooth remineralization versus demineralization[4]