Cariogenic bacterium in dental plaque biofilm

Cariogenic bacteria in dental plaque biofilm are acid-producing and acid-tolerating microorganisms that live within the complex, structured biofilm (dental plaque) adhering to tooth surfaces. While the oral biofilm comprises hundreds of bacterial species, mutans streptococci (notably Streptococcus mutans) and lactobacilli are especially associated with the development of dental caries, due to their ability to ferment dietary carbohydrates into organic acids (e.g., lactic acid), lowering pH and causing demineralization of tooth enamel. “Cariogenic bacteria” refers not to a single species or receptor, but rather a microbial phenotype (acidogenicity and aciduricity) within the polymicrobial biofilm; thus, the term is imprecise as a molecular target. Targeting these bacteria aims to reduce acid production, modify the biofilm matrix, or disrupt the conditions that support their predominance (e.g., frequent sugar intake, low saliva flow)[7][8][5]. - The term "Cariogenic bacteria in dental plaque biofilm" is not a molecular target or specific receptor, but rather describes a broad community phenotype or group within the multispecies oral biofilm[7][8][5]. - Interventions target multiple bacterial species (primarily *Streptococcus mutans*, *Lactobacillus* spp.), as well as biofilm structure and local environment, rather than a single, well-defined molecular entity. - For structured data, specific bacteria (e.g., "Streptococcus mutans") or molecular mechanisms (e.g., "glucosyltransferases in S. mutans") are preferable canonical targets.

Other names

Cariogenic oral bacteriumAcidogenic bacterium in dental plaqueMutans streptococcus (if referring to primary example)

Inhibition of bacterial adhesion, Disruption of biofilm matrix, Bactericidal or bacteriostatic effects, Inhibition of acid production, Enhancement of enamel remineralization (via fluoride)