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Target intelligence / Profile preview
Carnitine transporter (CT)
- Target
- CT
- Molecular classification
- Transporter, Membrane protein
01
Overview
Carnitine transporters are membrane proteins responsible for the uptake and translocation of carnitine and its derivatives, crucial for fatty acid metabolism. Key transporters include OCTN2 (SLC22A5) for cellular uptake and CAC (SLC25A20) for mitochondrial transport. These transporters facilitate the movement of long-chain fatty acids into mitochondria for beta-oxidation and are essential for energy production and preventing toxic accumulation of fatty acids. Defects in carnitine transporters can lead to severe metabolic disorders.
- Other names
- OCTN2SLC22A5CACSLC25A20Carnitine/acylcarnitine carrier
02
Mechanism of action
Facilitates the transport of carnitine and acylcarnitines across cellular and mitochondrial membranes, enabling fatty acid metabolism and beta-oxidation.
03
Biological functions
Fatty acid transportCarnitine transportAcylcarnitine transportBeta-oxidationEnergy productionMetabolic homeostasis
04
Disease associations
Primary carnitine deficiencyCarnitine-acylcarnitine translocase deficiencyHypoketotic hypoglycemiaCardiomyopathyLiver dysfunctionMuscle weaknessMetabolic crisis
05
Safety considerations
Potential for drug interactions affecting carnitine transportMetabolic complications in individuals with transporter deficiencies
06
Interacting drugs
Malonyl-CoA
1 more in the full profile.
07
Biomarkers
Carnitine levelsAcylcarnitine profile
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