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Target intelligence / Profile preview
Carnitine Transporter Protein (OCTN2)
- Target
- OCTN2
- Molecular classification
- Transporter, Membrane Transport Protein
01
Overview
SLC22A5 (OCTN2) is a sodium-dependent, high-affinity carnitine transporter protein essential for the uptake of carnitine into cells. It plays a critical role in fatty acid metabolism by transporting long-chain fatty acids into mitochondria. Mutations in SLC22A5 cause primary systemic carnitine deficiency, a potentially life-threatening disorder. Expression/activity can be modulated by PPARγ ligands, suggesting potential therapeutic avenues for metabolic diseases.
- Other names
- SLC22A5Organic Cation/Carnitine Transporter 2
02
Mechanism of action
Upregulation of SLC22A5 expression/activity (by PPARγ ligands)
03
Biological functions
Carnitine transportSodium-dependent carnitine symportOrganic cation transportFatty acid metabolismRenal reabsorption
04
Disease associations
Primary systemic carnitine deficiencyCardiomyopathyHypoglycemiaMuscle weaknessLiver dysfunctionNeurological disordersMetabolic disease
05
Safety considerations
Potential drug interactions due to organic cation transport activityRisk of carnitine deficiency if SLC22A5 function is impaired
06
Interacting drugs
Kaempferol
2 more in the full profile.
07
Biomarkers
Carnitine levels (serum, tissue)
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