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CARS1 antisense RNA 1 (CARS1-AS1)
- Target
- CARS1-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Non-protein coding RNA, Antisense RNA
01
Overview
CARS1 antisense RNA 1 (CARS1-AS1) is a long non-coding RNA gene identified in the human genome. It is classified as an antisense RNA, transcribed from the opposite DNA strand of the CARS1 gene, which encodes the enzyme cysteinyl-tRNA synthetase 1. Antisense RNAs typically regulate the expression of their sense gene partners through chromatin remodeling, transcriptional interference, or post-transcriptional regulation. While antisense RNAs have important modulatory roles in various biological processes including imprinting and chromatin dynamics, direct evidence for disease-relevant function, druggability, or established biomarker status of CARS1-AS1 is currently lacking. Some database associations highlight potential links to neurodevelopmental, hair, and growth disorders, but mechanistic and clinical validation remain open research areas.
- Other names
- CARS1-AS1CARS-AS1CARS antisense RNA 1CARS antisense RNA 1 (non-protein coding)
02
Biological functions
Regulation of gene expression at transcriptional and post-transcriptional levels (general function of antisense RNAs)May participate in regulatory mechanisms through modulation of the sense gene CARS1, influencing RNA and protein synthesis
03
Disease associations
MicrocephalyDevelopmental delayBrittle hair syndrome (potential disease association based on genetic studies; evidence for direct mechanistic role is limited)
04
Safety considerations
Targeting lncRNAs in general may have unknown risks due to widespread regulatory functions
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