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Cartilage Metabolism

Molecular classification: Metabolic Pathway

Overview

Cartilage metabolism refers to the complex biochemical processes within cartilage tissue, primarily involving chondrocytes. These metabolic activities are essential for maintaining the structure, function, and integrity of cartilage throughout life. Key pathways include glycolysis, oxidative phosphorylation, the tricarboxylic acid cycle, and the pentose phosphate pathway. Regulation is achieved through signaling molecules like PTHrP, IHH, IGF, and BMPs. Dysregulation is implicated in diseases like osteoarthritis.

Biological functions

Maintenance of cartilage extracellular matrixSynthesis of cartilage componentsEnergy production for chondrocytesRegulation of chondrocyte differentiation and maturation

Disease associations

OsteoarthritisChondrodysplasia

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