Cartilage metabolism modulation

Cartilage metabolism modulation refers broadly to altering the metabolic activity of chondrocytes and the dynamic balance between anabolic and catabolic processes that determine cartilage integrity. This includes regulating glucose uptake, glycolytic activity, mitochondrial function, oxidative stress, and the expression of key ECM components such as collagen II, aggrecan, and matrix-degrading enzymes (such as MMPs and ADAMTS5)[2][3][5]. Dysregulation of these metabolic processes, frequently induced by inflammation and aging, is central to the pathophysiology of osteoarthritis and cartilage degeneration. Therapeutic approaches seek to restore the balance of cartilage matrix metabolism by modulating specific enzymes, transcription factors, and signaling molecules involved in ECM synthesis/degradation, energy metabolism (e.g., AMPK, SIRT1), and inflammatory pathways[1][2][3][4][5][6].

Other names

Cartilage catabolismCartilage anabolismCartilage matrix metabolismChondrocyte metabolic pathwayCartilage tissue homeostasis