Cartilage synthesis pathways

“Cartilage synthesis pathways" collectively refer to the network of molecular and cellular signaling cascades that control the synthesis, maintenance, and remodeling of cartilage extracellular matrix, primarily by chondrocytes[1][2][4]. Key anabolic pathways include those activated by growth factors such as transforming growth factor-β (TGF-β), bone morphogenetic proteins (BMPs), insulin-like growth factor (IGF), fibroblast growth factors (FGFs), as well as the wnt, nitric oxide (NO), protein kinase C (PKC), and integrin-mediated signals[1][4]. These pathways regulate the expression of extracellular matrix components, including type II collagen, aggrecan, hyaluronan, and chondroitin sulfate[3][4][5]. Disruption or dysregulation of these pathways is implicated in cartilage degeneration seen in disorders such as osteoarthritis[1].

Other names

Cartilage formation pathwaysChondrogenesis pathwaysCartilage ECM synthesisCartilage anabolic signaling