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Target intelligence / Profile preview
Cartilage Tissue
- Molecular classification
- Connective Tissue
01
Overview
Cartilage is a specialized connective tissue providing structural support, shock absorption, and friction reduction in joints and other locations. It is composed of chondrocytes embedded in an extracellular matrix (ECM) containing collagen, proteoglycans, and glycosaminoglycans. Different types of cartilage (hyaline, fibrocartilage, elastic) exist, each with distinct properties and locations. Cartilage's avascular nature limits its regenerative capacity, posing challenges for therapeutic intervention. Emerging therapies target specific ECM components like type II collagen to enhance drug delivery and promote cartilage repair.
02
Biological functions
Structural supportShock absorptionFriction reduction in jointsTemplate for bone formation
03
Disease associations
OsteoarthritisChondrodysplasiaCartilage degradationJoint inflammation
04
Safety considerations
Limited regenerative capacityAvascularity hindering drug deliveryOff-target effects of ECM-targeting therapies
05
Biomarkers
Type II collagen fragmentsCOMP (Cartilage Oligomeric Matrix Protein)Hyaluronan
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