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Target intelligence / Profile preview
Casein Kinase 1 (CK1)
- Target
- CK1
- Molecular classification
- Enzyme, Serine/Threonine Kinase
01
Overview
Casein kinase 1 (CK1) is a family of serine/threonine-selective protein kinases found in all eukaryotes. CK1 enzymes are monomeric and function as key regulators in numerous cellular signaling pathways, impacting processes such as cell cycle progression, apoptosis, DNA repair, circadian rhythm regulation, and more. Mammals possess at least six or seven CK1 isoforms: alpha (α), beta (β), gamma 1–3 (γ1–3), delta (δ), and epsilon (ε). CK1 preferentially phosphorylates serine/threonine residues on substrates that are either preceded by acidic amino acids or primed by prior phosphorylation at nearby sites. Alterations in expression or activity levels of various CKI isoforms are linked to cancer development/progression as well as neurodegenerative diseases, making it a potential therapeutic target.
- Other names
- CSNK1Casein kinase I
02
Mechanism of action
Kinase inhibition
03
Biological functions
Cell cycle controlApoptosis regulationDNA repairCircadian rhythm maintenanceRibosome biogenesisVesicle traffickingSignal transductionWnt/β-catenin pathway modulationp53/Mdm2 axis modulationHedgehog/Shh pathway modulationHippo pathway modulationNF-kB signaling modulation
04
Disease associations
CancerNeurodegenerative disease
05
Safety considerations
Potential for off-target effects due to kinase family homologyAltered substrate preference via autophosphorylation
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