Target intelligence / Profile preview

Casein Kinase 1 Alpha (CK1α)

Target: CK1α
Molecular classification: Enzyme, Serine/threonine protein kinase

Overview

Casein kinase 1 alpha (CK1α) is a serine/threonine-specific protein kinase involved in various cellular processes, including cell cycle regulation, apoptosis, and Wnt signaling. Dysregulation of CK1α has been implicated in cancer and other diseases, making it a potential therapeutic target.

Other names: CSNK1A1

Mechanism of action

CK1α phosphorylates target proteins on serine and threonine residues, thereby modulating various signaling pathways.

Biological functions

Regulation of membrane traffickingCell cycle progressionChromosome segregationApoptosisAutophagyCell metabolismDifferentiation during developmentCircadian rhythm regulationImmune response modulationWnt/β-catenin signalingNF-kB signalingHedgehog signaling

Disease associations

CancerNeurodegenerative disease

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