Casein kinase 1 alpha 1 like (CSNK1A1L)

Casein kinase 1 alpha 1 like (CSNK1A1L) is a serine/threonine protein kinase belonging to the CK1 family, involved in signal transduction, negative regulation of canonical Wnt signaling, and phosphorylation of various substrate proteins. It localizes primarily to the cytoplasm and nucleus, and its function has been implicated in the regulation of β-catenin stability, cell cycle progression, and potentially in the modulation of p53 and NF-κB signaling. CSNK1A1L is associated with multiple physiological processes and disease states, such as cancer, neurodegeneration (Alzheimer's disease), and hematologic malignancies. Although not as extensively studied as the closely related CSNK1A1 (CK1α), this kinase shares key functional, substrate, and regulatory features within the CK1 family, suggesting a potential as a drug target and biomarker in relevant contexts

Other names

Casein kinase I isoform alpha-likeCSNK1A1LCKI-alpha-likeMGC33182CK1casein kinase I alpha S-likecasein kinase 1 alpha 1 likecasein kinase 1 α 1 like

Ubiquitination and proteasomal degradation of the kinase (e.g., by lenalidomide); Direct kinase inhibition (e.g., by small-molecule inhibitors like D4476)