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Target intelligence / Profile preview
Casein Kinase 1 Delta (CK1δ)
- Target
- CK1δ
- Molecular classification
- Enzyme, Serine/Threonine Kinase, Protein Kinase
01
Overview
Casein kinase 1 delta (CK1δ) is a serine/threonine-specific protein kinase involved in the regulation of circadian rhythm, Wnt signaling, and DNA repair. It phosphorylates various substrates, influencing processes such as cell growth, survival, and the stability of core clock proteins. Aberrant CK1δ activity has been implicated in neurological disorders like Alzheimer's disease and various cancers, making it a potential therapeutic target.
- Other names
- Casein kinase I isoform deltaCKI-deltaHCKIDCasein kinase I delta
02
Mechanism of action
Kinase inhibitor
03
Biological functions
Circadian rhythm regulationWnt signalingDNA repairCell cycle regulationCell proliferationSignal transduction
04
Disease associations
Sleep disordersAlzheimer's diseaseCancerNeurological disordersCircadian rhythm disorders
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