Casein kinase 1 gamma-3 (CSNK1G3)

Casein kinase 1 gamma-3 (CSNK1G3) is a member of the CK1 family of serine/threonine protein kinases, characterized by its ability to phosphorylate casein and many acidic proteins[1][4][6]. It is encoded by the CSNK1G3 gene on human chromosome 5q23.2 and functions in diverse cellular processes, including cytokinesis, DNA repair, nuclear localization, protein transport, and especially key roles in **Wnt signaling**, where it phosphorylates the co-receptor LRP6 to promote pathway activation[1][4][7]. CSNK1G3 is widely expressed and implicated in the regulation of fast synaptic transmission via glutamate and potentially other neural processes[1]. Disease links include cancer, sarcosinemia, and specific brain development disorders, though clinical targeting remains investigational[1][5][7].

Other names

CKI-gamma 3CK1-gamma 3CSNK1G3LCasein kinase I isoform gamma-3Casein kinase I gamma 3

Inhibition of kinase activity (serine/threonine phosphorylation)[6]. Modulation of Wnt signaling by phosphorylation of pathway components[7][4].