Casein kinase II (CK2)

Casein kinase II (CK2) is a highly conserved, constitutively active serine/threonine protein kinase with broad roles in cellular regulation and disease. It typically exists as a heterotetramer composed of two catalytic α subunits (either α or α′ isoforms) and two regulatory β subunits. CK2 regulates numerous cellular processes, including cell cycle progression, DNA repair, stress signaling, and gene expression. It is essential for cell viability and is overexpressed or hyperactive in many cancers, making it a target for anti-cancer drug development. It is also a drug target in fungal infections such as Cryptococcus neoformans.

Other names

Protein kinase CK2Casein kinase 2CSNK2

CK2 inhibitors (in development) target the ATP-binding site of the kinase, inhibiting its activity