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Target intelligence / Profile preview
Casein Kinase 2 Alpha Prime (CK2α')
- Target
- CK2α'
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase
01
Overview
Casein kinase 2 alpha prime (CK2α') is a catalytic subunit of the serine/threonine protein kinase enzyme complex, casein kinase 2 (CK2). CK2 is a highly conserved and ubiquitously expressed protein kinase involved in numerous cellular processes including cell cycle control, DNA repair, apoptosis suppression, and circadian rhythm regulation. Overexpression of CK2α' has been observed in certain cancers such as classical Hodgkin lymphoma, thus it may represent a potential therapeutic target.
- Other names
- Casein kinase 2, alpha prime polypeptide subunitCK2-A2CSNK2A2
02
Mechanism of action
Kinase inhibitor
03
Biological functions
Cell growthCell proliferationCell cycle controlDNA damage repairApoptosis suppressionCircadian rhythm regulationPhosphorylation
04
Disease associations
CancerSpermatogenesis impairment
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