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Target intelligence / Profile preview
Casein kinase 2 alpha subunit (CK2α)
- Target
- CK2α
- Molecular classification
- Enzyme, Protein Kinase, Serine/threonine protein kinase
01
Overview
Casein kinase 2 alpha subunit (CK2α) is the catalytically active component of casein kinase II (CK2), a highly conserved serine/threonine protein kinase. It plays a central role in numerous cellular processes, including cell cycle control, DNA repair, and regulation of circadian rhythms. Deregulation or overexpression of CK2 has been linked to cancer development due to its anti-apoptotic properties.
- Other names
- Casein kinase II alpha subunitCSNK2A1CKIIalpha
02
Mechanism of action
Kinase inhibitor
03
Biological functions
Cell cycle controlDNA repairRegulation of circadian rhythmAnti-apoptotic signalingSignal transductionCell survival
04
Disease associations
CancerTumorigenesis
05
Safety considerations
Inhibition may lead to cell deathOff-target effects due to broad substrate specificity
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