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Target intelligence / Profile preview
Casein Kinase I (CK1)
- Target
- CK1
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase
01
Overview
Casein Kinase I (CK1) is a family of highly conserved serine/threonine protein kinases found in all eukaryotes. They play crucial roles in regulating diverse cellular processes, including signal transduction, cell cycle progression, DNA repair, apoptosis, circadian rhythm regulation, vesicle trafficking, and more. Alterations in CK1 expression or activity are linked to various diseases, including cancer and neurodegenerative diseases. CK1 is being explored as a potential target for cancer therapy.
- Other names
- CKICSNK1A1CSNK1DCSNK1ECSNK1G1CSNK1G2CSNK1G3
02
Mechanism of action
CK1 inhibitors are being explored, but no specific mechanisms listed in the provided context.
03
Biological functions
Signal transductionCircadian rhythm regulationCell cycle progressionDNA repairApoptosisVesicle traffickingWnt/β-catenin signalingHedgehog pathwayHippo pathway
04
Disease associations
CancerNeurodegenerative diseaseInfectious disease
05
Safety considerations
Dysregulation contributes to carcinogenesisMisregulation of key signaling cascades
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