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Target intelligence / Profile preview
Casein Kinase I Alpha (CK1α)
- Target
- CK1α
- Molecular classification
- Enzyme, Serine/threonine kinase, Protein Kinase
01
Overview
Casein kinase I alpha (CK1α) is a serine/threonine-specific protein kinase that regulates multiple signaling pathways and cellular functions, including membrane trafficking, cell cycle progression, apoptosis, and immune response modulation. It is a therapeutic target for various diseases including cancer and neurodegeneration.
- Other names
- CSNK1A1
02
Mechanism of action
CK1α acts primarily as a monomeric serine/threonine protein kinase, phosphorylating substrates at specific serine and threonine residues.
03
Biological functions
Membrane traffickingCell cycle progressionChromosome segregationApoptosisAutophagyCell metabolismCell differentiationCircadian rhythm regulationImmune response modulationSignal transduction
04
Disease associations
CancerNeurodegenerative disease
05
Safety considerations
Inhibition of CK1α can have broad effects on cellular signaling pathways.Potential for off-target effects due to the conservation of kinase domains across different kinases.
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