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Target intelligence / Profile preview
Casein Kinase I Delta (CK1δ)
- Target
- CK1δ
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase
01
Overview
Casein kinase I delta (CK1δ) is a serine/threonine-specific protein kinase involved in regulating diverse cellular processes, including circadian rhythm, microtubule dynamics, Wnt signaling, and DNA repair. It is considered a therapeutic target due to its involvement in cancer and neurodegenerative diseases. The activity of CK1δ is modulated through phosphorylation within its C-terminal domain. There is active research into developing selective inhibitors that account for regulatory modifications such as C-terminal phosphorylation states.
- Other names
- CKI-deltaCSNK1D
02
Mechanism of action
Kinase inhibitor
03
Biological functions
Circadian rhythm regulationMicrotubule dynamicsWnt signalingDNA repairCell cycle controlSignal transduction
04
Disease associations
Sleep disordersCircadian disordersNeurodegenerative diseaseCancer
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