Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Casein Kinase I Epsilon (CK1ε)
- Target
- CK1ε
- Molecular classification
- Enzyme, Serine/threonine kinase, Casein kinase I family
01
Overview
Casein kinase I epsilon (CK1ε), also known as CSNK1E, is a serine/threonine protein kinase and a member of the casein kinase I family. It functions primarily as a monomer in the cytoplasm and can autophosphorylate its own C-terminal domain. CK1ε plays a central role in regulating the circadian clock by phosphorylating Period family proteins (PERs). It is also implicated in cell cycle control, DNA repair, and Akt pathway regulation. CK1ε phosphorylates proteins at Ser(p)XXSer/Thr motifs.
- Other names
- CSNK1E
02
Mechanism of action
ATP-competitive inhibition of kinase activity
03
Biological functions
Circadian rhythm regulationCell cycle regulationDNA repairApoptosisAkt pathway regulationProtein phosphorylation
04
Disease associations
Circadian rhythm disordersCancerOsteoarthritis
05
Interacting drugs
PF-670462
Beyond the preview
Go deeper on Casein Kinase I Epsilon (CK1ε).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Casein Kinase I Epsilon (CK1ε).