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Target intelligence / Profile preview
Casein Kinase I Isoform Alpha (CK1α)
- Target
- CK1α
- Molecular classification
- Enzyme
01
Overview
Casein Kinase I Isoform Alpha (CK1α) is an enzyme that plays a crucial role in various cellular processes including signal transduction, cell cycle regulation, transcription, and intermediate filament cytoskeleton organization. It is involved in the phosphorylation of numerous proteins, impacting pathways critical for tumorigenesis, such as Wnt signaling. CK1α's activity is also linked to apoptosis signaling and cell motility, making it a potential therapeutic target for cancer treatment.
- Other names
- Casein Kinase 1, Alpha 1CK1αCSNK1A1
02
Mechanism of action
Phosphorylation of key regulatory proteins involved in cell cycle, transcription, and signal transduction. Inhibition of CK1α can affect Wnt signaling, apoptosis, and other pathways.
03
Biological functions
Signal transductionCell cycle regulationTranscription regulationIntermediate filament cytoskeleton organizationApoptosis signalingCell motility regulation
04
Disease associations
CancerTumorigenesis
05
Safety considerations
Potential off-target effects due to the broad substrate specificity of CK1α
06
Biomarkers
Specific biomarkers for CK1α are not well-documented in the search results. However, its role in Wnt signaling and cancer progression could be relevant.
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