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Target intelligence / Profile preview
Casein kinase I isoform epsilon (CK1ε)
- Target
- CK1ε
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase, Casein Kinase I Family
01
Overview
Casein kinase I isoform epsilon (CK1ε) is a serine/threonine protein kinase that plays a critical role in various cellular processes, most notably the regulation of mammalian circadian rhythms. It is a member of the casein kinase 1 family and shares high sequence similarity with CK1δ. CK1ε phosphorylates a wide array of substrates and is involved in DNA replication, DNA repair, and the modulation of cytoplasmic and nuclear signaling pathways. Due to its involvement in diverse processes, it has been implicated in cancer progression, neurodegenerative diseases, diabetes, and cartilage destruction. CKIε is considered a therapeutic target, and selective inhibitors like PF-670462 have been developed.
- Other names
- CSNK1E
02
Mechanism of action
Inhibition of CK1ε kinase activity
03
Biological functions
Signal transductionCircadian rhythm regulationDNA replicationDNA repairCell cycle controlWnt signaling cascade modulation
04
Disease associations
CancerNeurodegenerative diseaseDiabetesOsteoarthritis
05
Interacting drugs
PF-670462
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