Casein kinase I isoform epsilon (CK1ε)

Casein kinase I isoform epsilon Overview

Casein kinase I isoform epsilon (CK1ε) is a serine/threonine protein kinase that plays a critical role in various cellular processes, most notably the regulation of mammalian circadian rhythms. It is a member of the casein kinase 1 family and shares high sequence similarity with CK1δ. CK1ε phosphorylates a wide array of substrates and is involved in DNA replication, DNA repair, and the modulation of cytoplasmic and nuclear signaling pathways. Due to its involvement in diverse processes, it has been implicated in cancer progression, neurodegenerative diseases, diabetes, and cartilage destruction. CKIε is considered a therapeutic target, and selective inhibitors like PF-670462 have been developed.

Mechanism of Action

Inhibition of CK1ε kinase activity

Biological Functions

Safety Considerations

Interacting Drugs