Casein kinase I isoform gamma-2 (CSNK1G2)

Casein kinase I isoform gamma-2 (CSNK1G2) is a member of the casein kinase 1 (CK1) family of serine/threonine protein kinases, which are monomeric enzymes involved in the phosphorylation of a broad array of substrates, especially those with acidic residues such as caseins[1][2][3]. The CK1γ subfamily includes CK1γ1, CK1γ2, and CK1γ3, all encoded by distinct genes but sharing a conserved kinase domain[2]. CSNK1G2 localizes to cellular membranes and is involved in diverse cellular processes, including the regulation of canonical Wnt signaling—particularly through phosphorylation of co-receptors and other pathway participants[3][5]. It also plays roles in the regulation of endocytosis, synaptic vesicle trafficking, neurotransmitter release, and the modulation of reactive oxygen species[1][9]. Disease associations for CSNK1G2 are emerging, including links to some genetic neurodevelopmental disorders and familial febrile seizures[1][8]. Altered function or expression of CK1 isoforms (including CK1γ2) may contribute to tumorigenic processes through dysregulation of signaling networks such as Wnt/β-catenin[5]. CSNK1G2 is considered a legitimate druggable enzyme but currently lacks any approved selective therapeutic modulators[1][5][12].

Other names

Casein kinase 1 gamma 2CK1G2CKI-gamma 2CK1g2casein kinase I isoform gamma-2casein kinase I

Kinase inhibition (for compounds that would inhibit CSNK1G2 enzymatic activity) - Modulation of Wnt signaling pathway (by affecting substrate phosphorylation)