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Target intelligence / Profile preview
Casein Kinase II Alpha (CK2α)
- Target
- CK2α
- Molecular classification
- Enzyme, Serine/threonine protein kinase
01
Overview
Casein kinase 2 alpha (CK2α) is the catalytic subunit of casein kinase II, a highly conserved and ubiquitously expressed serine/threonine protein kinase. It plays a central role in multiple cellular processes including cell growth, proliferation, apoptosis suppression, cell cycle regulation, DNA damage repair, and stress signaling. Overexpression or dysregulation of CK2α is associated with various cancers, making it a target for therapeutic intervention.
- Other names
- Casein kinase 2 alphaCKIIαCSNK2A1
02
Mechanism of action
Inhibition of CK2α kinase activity
03
Biological functions
Cell growth and proliferationSuppression of apoptosisRegulation of cell cycle transitionsDNA damage repairStress signalingPhosphorylation
04
Disease associations
CancerColorectal cancerClassical Hodgkin lymphoma
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